Aging brain cells sometimes forget who they are. This was discovered by researchers from the University of Innsbruck, who grow “mini brain”-so-so-so-so-called organoids of human stem cells that they grow in laboratory bowls and activated in these artificial aging processes.
Markers then reports markings about the genetic composition of the brain nerve cells that determine their identity reports, Frank Edenhofer of the University of Innsbruck, who for the first time with his research colleagues could show that organoids can agate, in a broadcast of the broadcast of the broadcast of the broadcast of the Science Fund (FWF) broadcast.
Miniature organoids of stem cells are excellent test models for human organs such as heart and brain, but the business is so far a catch for age research, said Edenhofer of the Institute for Molecular Biology at the University of Innsbruck: “It is very young tissue, similar to A fetus. “There are, however, known diseases because of genetic defects that cause early aging, for example with the proger protein.
Researchers brought mini -brain to “rust”
The researchers now brought the template (the gene) for a changed process in the brain organoid and were then able to observe aging processes with which they are observed. As in real human brains of the advanced age, the activity of the “cell power plants” (mitochondria) and the “resting” mini brain literally decreases for you, said Edenhofer. Both in their cells and iron, oxygen causes “oxidative damage”, which accumulate over time and affect the function.
To the extent that the “rust damage” on the genome, the “epigenetic markers”, according to the cell type, there, according to the stem cell researcher, he has erected a gene that is important for both the genome repair and for the preservation of these epigenetic markers.
Search for neuro fountain
The researcher also wants to check whether you can rejuvenate brain nerve cells with different pharmacological interventions. There are a number of substances that are considered, for example spermidine, he said: “We can now analyze their way of operation in a model for the first time and perhaps discover new active substances and strategies.”
With the mini-hersenes it would be possible to investigate the development of neurodegenerative diseases such as M. Alzheimer or M. Parkinson’s in the laboratory. Together with Luxembourg colleagues, the Innsbruck researchers have grown and old MINI brain, in which the early effects of Parkinson’s diseases can be seen.
Source: Krone
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