Wissenschaftler of the Universität Bern Haben Einen Neinen Ansatz Zur Bekämpfung von Coronaviren Entdeckt. Sie untersucht dafür einen mechanism, with dem das coronavirus menschliche zellen manipuliert, um sich zu vermehren.
The findings can promote the development of antiviral drugs – with regard to possible future coronavirus epidemics, such new antiviral active ingredients are urgently needed, said the University of Bern Tuesday
The NSP1 protein is one of the first virus proteins produced in the human cell in infection by coronaviruses. Earlier studies had already shown that a central function of NSP1 is to have the host cell produced more virus proteins than cell own proteins.
In Ihrer Study Unters Airs that dies in violent mechanisms Nun Genauer. Die Forschungsergebnisse wurden in the Fachzeitschrift “Cell Reports” Veröffentlicht. Darin Zeigten sie, Dass es Dem Protein Durch Zwei Unabhängige Mechanisms, who Infizierte Wirtszelle Zur Produkttion von Mehr Virusproteinen Zu Bringen. Einerseits hemmt es that Produkttion von Zelleigenen Proteinen, und Anderserseits Zerstört es sucked that Zelleigene mrna, Welche Die Bapläne für lebensomente wirtsprotein Enthält.
However, the second function – the destruction of the host – MRNA – does not occur in all coronaviruses. According to the University of Bern, the results of the study suggest that medication development should be aimed at the binding of NSP1 to human ribosomes, and not on dismantling mrna.
Source: Krone
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