The Graz University researcher Nermina Malanovic registers two patents: Protein molecules are intended to destroy multidrug-resistant pathogens. The “Krone” knows what’s behind it.
The University of Graz has found a way to control hospital bacteria. The multi-resistant pathogens, which can easily spread in hospitals, must be combated with peptides. The small protein molecules are intended to damage and kill the cell membranes of the pathogens. Peptides are not only effective against bacteria, but also against fungi, viruses and even cancer cells, the University of Graz announced on Monday.
Researcher Nermina Malanovic from the University of Graz was successful in the fight against the pathogens: “Especially multi-resistant germs often have complex bacterial envelopes, which makes treatment so difficult.”
Against bacteria, viruses and cancer cells
Thanks to new research results, it is now possible to combine different peptides in such a way that their effect against pathogens is increased. “Peptides kill bacteria, fungi, lipid-containing viruses like the coronavirus, and even cancer cells,” says Malanovic. The pathogens are destroyed so quickly that resistance cannot develop.
Even the dreaded hospital bacteria could be destroyed in this way. “In addition, peptides are anti-inflammatory and can be used where pathogens attack the immune system,” says the biochemist, citing viral diseases such as Covid-19 as an example. The course is often aggravated by a secondary infection with bacteria or fungi.
Large-scale use has so far failed due to the currently very high costs. 100 milligrams of peptides would cost about 2000 euros. And only special laboratories can produce these substances.
“First Step to Victory”
One goal of her work is therefore to develop a strategic design for such active molecules. The new scientific findings could easily be used to design new peptides and optimize the production process: ‘This is a first step towards defeating super-resistant bacteria.’ She developed two fabrics herself and applied for patents at the University of Graz.
Deaths from germs continue to occur in hospitals.
Source: Krone

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