An American has given himself increasingly larger doses of snake toxins, so that he was finally able to bite the animals. This makes an extraordinary medical development possible.
A major problem to develop antidote to snake bites is that the toxins often consist of a cocktail of different toxins that have a different effect. Normally opposite toxins would be developed by giving horses or sheep the poison of individual snake species and isolating the antibodies formed, researchers from Columbia University in New York and the Medical Development Centivax.
This procedure can be effective, but also has serious side effects if the non-human antibodies were used in humans. Moreover, these such anti -fabric only work against the toxins of the respective snake species. In this case it is different.
“Unique immunzeste history”
“The most exciting thing about the donor was his unique immunogio history,” said first author Jacob Glenville. The American peace was bent a hundred times of a total of 16 different, very toxic snakes for a period of 18 years. He survived and is now working at Centivax.
From his blood the researchers insulated two particularly broad antibodies and combined with an enzyme inhibitor in an active ingredient that is supposed to protect against different toxins from different poison snakes. In the study this was tested on mice that previously administered toxins. The agents of complete protection against toxins of 13 snake species, including the Königskobra, the Black Mamba and the Indandeland Taipan, the most poisonous snake in the world. The cocktail offered at least partial protection against six species.
Resources must now be tested for dogs
The research team admitted that this success of mice is not yet sufficient. The antidote must now be tested in veterinary clinics on dogs that are bitten by snakes. It was also believed that the effect on the Gifslangen group was limited and that the study only focuses on the life -saving effect of the opposite poison.
So there are often lifelong physical limitations of snake toxins. According to the researchers, more than 100,000 people die every year of poisoning from snakes, 300,000 more permanent disabilities of them, such as loss of eyesight or the amputation of limbs.
Source: Krone
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