The positive effect of the Covid vaccinations on the course of the disease is still undisputed. However, according to new data from the US, it is worth looking at which vaccine can be administered with the booster vaccination. For example, the adapted vaccination reduces the risk of death by a factor of 14.1 compared to unvaccinated people.
The vaccine adapted to Omikron BA.4/BA.5 is also significantly more effective than a “booster” with the old monovalent vaccine (mortality reduced by a factor of 5.4), as shown by the current study with 21.3 million people between October 2021 and Performances December 2022.
Effect hits the target
The research was conducted by scientists at the US National Centers for Disease Control and Prevention (CDC/Atlanta/Georgio). Although there was a high infection rate in the US with the Omicron wave caused by BA.4/BA.5, the effect of a “booster” with a modified vaccine was fully effective in severe diseases.
For the period from September 18 to December 24, 2022, when the vaccination process was dominated by BA.4/BA.5 variants, the team found that the risk of infection was 2.8 times higher for unvaccinated people than for humans who had been vaccinated. bivalently reinforced. Compared to the monovalent boosters, the risk was a factor of 2.5 higher. “The additional protection of the bivalent vaccination against infection with BA.4/BA.5 was therefore limited,” the Deutsches Ärzteblatt wrote on Tuesday.
Greatest protective effect in older people
The picture was different when it came to preventing serious illnesses and deaths: “Unvaccinated people had a 14.1 times higher risk of dying after infection with SARS-CoV-2 than people who received the bivalent ‘booster’ . Compared to people who had received a monovalent ‘booster’, the risk of death was increased by a factor of 5.4. The relative risks were significant in all calculations (statistic; note) due to the high number of cases.
The greatest protective effect occurred in the age group of 65 to 79 years. The death rate from Covid-19 in unvaccinated people was 8.3 times higher than with a booster with the old vaccine. Compared to the vaccine adapted to Omikron BA.4/BA.5 and a booster, the mortality rate in non-immunized patients was even 23.7 times higher.
Source: Krone
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