There are a wide variety of insidious diseases in which the immune system attacks its own body or causes inflammation for no reason, such as chronic intestinal diseases. Doctors want to have discovered closely related causes in them and assume that there are so-called ‘key genes’.
According to this, multiple sclerosis, “butterfly rash” (lupus erythematosus) and diabetes (type 1) should also have many parallels in their development. They comprise a certain network that normally regulates the immune system in a hereditary way. This is according to a study published in the journal Science Advances.
Found by computer analysis
A team led by Kaan Boztug and Julia Guthrie of the Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences (ÖAW) used computer network analysis to investigate how the causative agents of 186 rare diseases are linked.
network of involved genes
These are mainly autoimmune and autoinflammatory diseases in which the immune system attacks its own tissue and causes inflammation without an external cause. The researchers identified a network of interacting key genes that can cause such diseases. “In autoimmune and autoinflammatory diseases, they’re right at the center of the genes involved,” says Guthrie.
“Using the evaluation, the diseases were reclassified and we calculated which therapies could yield the best results for the respective groups,” said a CeMM broadcast. The predictions about which therapies show promise should be “significantly more accurate than with the previous approach,” says Boztug.
Source: Krone
I am an experienced and passionate journalist with a strong track record in news website reporting. I specialize in technology coverage, breaking stories on the latest developments and trends from around the world. Working for Today Times Live has given me the opportunity to write thought-provoking pieces that have caught the attention of many readers.
