Covid immunity explained by chief immunologist – why some people don’t catch the virus

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The lead doctor explained why some people did not contract Covid-19. He said there are four main reasons why some people are immune, and he has begun new research to study them.

Speaking on Ireland’s Claire Byrne TV Show, Dublin immunologist Dr Cliona O’Barelli said some people have managed to escape Covid-19 because of their socioeconomic background, good general health, cautious behavior and rare innate immunity. Reply.

We’re researching,” said Dr. Oparelli, who is also a professor of comparative immunology and biochemistry at Trinity College. “The innate immune signals that define resistance, so I think these four things are really important: your socioeconomic status, your overall health, how you act and then this innate resistance.”

Dr. O’Farrell has also spent several years researching women with hepatitis C through blood transfusions and why some women have not contracted the virus. This is thought to be due to the innate similarity of the immune response to Covid-19, according to a DublinLive report.

He explained, “Now we have data that uninfected women have a more innate immune response. It’s an immune response that starts immediately when you encounter a virus and is part of the immune system that’s exactly where the virus is. A lot of people are uninfected because they’re very careful and we have to congratulate them.” “But besides people who don’t take it because they are very careful, there are people who have an innate immune system and we think that the innate immune system can prevent infection with the virus.”

Dr Oparelli said there is currently a huge international consortium studying people from 40 countries who have not contracted Covid-19 despite their close contact with the virus. Currently, they are looking for people from Ireland who have never used Covid to participate in a major study.

Dr. Oparelli said: “Ideally we’re looking for people who have fought off the virus twice, during the first wave and more recently with Omicron, and ideally we need people whose partner was positive before they shared a room with them. And they stayed. PCR negative.”

He said the study was looking for “genetic markers” of infection resistance. He added, “This means that you have to sort out the entire genome of people, and it’s like looking at a haystack because the human genome is very variable, but we would expect to see some mutations in the innate immune gene that makes humans resistant.”

When asked about the recent increase in his hospitalization with Covid, Dr. Oparelli added: “People still have to be careful, because there are still vulnerable people who are already suffering and this is the health system, health workers are overburdened and they have he-she. I work on the skeleton. , causing enormous difficulties. We really need to take care of them now.”

We may expect more options to emerge, Dr. O’Farrell said: “Unfortunately, this will continue. This virus is circulating and that is why we are privileged in this country to vaccinate multiple times and release multiple vaccines. It will come back as long as the whole world already does. It will be immune.”

Learn more about the new research on Covid-19 resistance here.

Source: Belfastlive

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